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When applied in cell culture, asparaginase inhibited cell growth and induced cell death in pancreatic cancer cells

VC, vascular calcification

A potential strategy that can selectively induce cuproptosis in cancer cells is to modulate copper levels within the tumor microenvironment since cancer cells have a higher demand for this metal nutrient compared to normal cells

However, further epidemiological studies and mechanistic research are required to confirm these results and provide scientific evidence and practical guidance for primary prevention of GDM

Under conditions of oxidative stress, elevated levels of reactive oxygen species (ROS) oxidise key cysteine residues in KEAP1 (C226, C273 and C288), altering its conformation, thereby impairing the degradation of NRF2