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Environmental-induced oxidative stress in neurodegenerative disorders and aging

FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012

Therefore, these materials should be avoided during the sample preparation

The presence of these aggregates is a hallmark of PD and is closely associated with the progression and symptomatology of the disease (38)

It takes 4 to 8 weeks before results (if any) are seen