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This particular interaction is absent in Theta, Sigma, Beta, and Tau members and is replaced by an extensive network of polar interactions (Figure 5C) (Armstrong, 2000)

It is not approved by any regulatory authority and has not been evaluated for safety or efficacy in humans

Temperature excursions above 8C cause irreversible peptide denaturation

However, the variety of candidates (RNAs, small molecules, lipids, inorganic compounds, dietary supplements) suffers from the still incipient clinical investigation methods, which represent only 8% of the recently published papers on the matter (178)