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4e), in line with an enriched binding of p53 to a binding site in the Angptl4 gene (Supplementary Fig

HMGB1 then activates danger-associated molecular pattern (DAMP) signaling, triggering microglial activation and proinflammatory cytokine release, thereby intensifying neuroinflammation and causing further disruption of the blood-brain barrier (205)

doi: 10.1016/j.jss.2012.03.051 80 HautzTHickethierTBlumerMJBitscheMGrahammerJHermannMet al

Findings from several randomized placebo-controlled trials suggest pirfenidone may slow disease progression (Azuma 2005

Therefore, these results showed that high serum Li levels were closely and positively associated with unexplained miscarriage