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It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

Currey, J

The Rome diagnostic criteria frequently overlap with symptoms of other organic GI diseases, making differentiation challenging

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It eliminates the need for supplies, making it suitable for subjects that may experience discomfort or stress from injections or for researchers who prefer non-invasive methods