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Angina (severe chest pain) or Arrhythmia (irregular heartbeat), uncontrolled or Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 3 months) or Heart failure (within the last 6 months) or Hypertension (high blood pressure), uncontrolled or Hypotension (low blood pressure) or Retinal disorders (eye problem) or Retinitis pigmentosa (an inherited eye disorder) or Stroke (within the last 6 months)Should not be used in patients with these conditions

Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis

10.1371/journal.pone.0186700 78 LucaM.LucaA

There is concern and controversy about their long-term use [16]

Although there are some links between TMAO and MAFLD and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in animal models, whether reducing TMAO concentrations could prevent MAFLD remains unclear due to lack of relevant studies