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Pathway topologybased enrichment statistics derived from the metabolitemetabolite interaction network for pre- and post-GF-MKD samples are provided in Supplementary Table S7

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In addition, carnitine supplements, such as levocarnitine, can be used to increase carnitine levels in the body, which combines with glutaryl CoA to scavenge organic acids to control symptoms

Previous studies have suggested that SPA can induce DNA damage and downregulation of homologous recombination repair (HRR) gene expression in prostate cancer cell lines (12) and that patients with HRR genomic alterations may have heightened clinical responses to BAT (12, 30)