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However, despite encouraging early laboratory findings, its clinical development was discontinued in 2007 after failing to demonstrate significant weight-loss efficacy in large-scale human trials

Haider S, Gamperl M, Burkard TR, Kunihs V, Kaindl U, Junttila S, Fiala C, Schmidt K, Mendjan S, Knofler M, Latos PA (2019) Estrogen Signal Drives Ciliogenesis Hum Endometrial Organoids Endocrinol 160:22822297

These include: Nausea Diarrhoea Vomiting Constipation Stomach pain There is also a risk of serious side effects, although these are less common

They are often incorporated into comprehensive anti-aging and optimization protocols