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Careful handling minimizes the risk of contamination or degradation, which is especially important when studying its impact on skeletal muscle function, body weight regulation, and mitochondrial activity in animal models

These can be signs of an early B12 deficiency or other nutritional deficiencies like folate, vitamin B2 (riboflavin), and vitamin B3 (niacin) deficiency

There are a variety of animal products that are excellent sources of methylcobalamin

Suggested cutoffs and the interpretation of values of the combined 4cB12 indicator for use by researchers and clinicians and for epidemiologic purposes are shown in Table 22b.10