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When injection becomes routine, the anxiety component disappears

Then you don't know where the tipping point is, and then somebody can have a really terrible reaction

Hartmann D, Drummond J, Handberg E, Ewell S, Pozzo-Miller L (2012) Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders

Urits I, Capuco A, Sharma M, Kaye AD, Viswanath O, Cornett EM, et al

According to the NHS, the usual pattern depends on the cause: Non-dietary cause (for example an absorption problem): an injection of hydroxocobalamin every two to three months, usually for life