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Route Intranasal solution is the most-studied format

E.et al (2018)

However, the poor fidelity to the in vivo conditions limits its efficacy, widening the translational gap between preclinical studies and clinical trials ( Hydrogel-based cell culture systems, spheroids and organoids, or their combination currently represent valid 3D cell culture models ( e.g

10.1002/cphy.c150032 61

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