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RodriguezJLLMayer-FlixEARuiz-EspinozaFHGuevara-FrancoJA

As research advances, integrating genetic, molecular, and clinical insights will be critical to developing effective therapies that not only alleviate symptoms, but also modify the course of the disease and improve the lives of patients and their families

Laboratory studies of murine and non-human primates have demonstrated increased liver fat, hepatic inflammation, oxidative stress, and mitochondrial dysfunction in offspring of obese mothers fed a high-fat diet,(Reviewed in 9,33 ) The results of our metabolomic analysis of cord plasma add to the existing literature and suggest that lipotoxicity and increased oxidative stress also occur in infants born to mothers with obesity

Studies also document TB-500's effects on basic fibroblast growth factor and vascular endothelial growth factor expression, both involved in blood vessel formation processes