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While overall decline rates were similar between groups, post-hoc subgroup analysis indicated slower cognitive decline in early-onset patients (aged 65 or younger) compared to placebo, as measured by the Alzheimer's Disease Assessment Scale cognitive subscale and Clinical Dementia Rating Scale [5][18]

Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers

The results of long COVID investigations cautiously suggest that impaired metabolism and neuronal dysfunction may play a role in mental fatigue, similar to hypotheses for ME/CFS

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