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PC-9 and NCI-H1975 cells were treated with Cu-DMSA-HA or cisplatin at concentrations of 0.5, 1, 1.5, and 2 their respective IC values, and cell viability was evaluated at 24, 48, and 72 h

Nature 618 , 151158 (2023)

In addition to glutathione-dependent protective system (glutathione, glutathione reductase, and glutathione peroxidase), cellular peroxides level is controlled by thioredoxin system (thioredoxin, thioredoxin reductase, and thioredoxin peroxidase) (73, 74)

DNA methylation and depression Studies have found that stress-related MDD is associated with DNA methylation changes in multiple human genes

Under physiological conditions, mitochondria regulate intracellular redox homeostasis while producing limited ROS as a byproduct of oxidative phosphorylation