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Illustratively, BPC 157 (as an original anti-ulcer peptide, stable in human gastric juice more than 24 h unlike standard growth factors rapidly destroyed, and thereby easy applicable, lethal dose (LD1) not achieved, used to be in ulcerative colitis trials and now multiple sclerosis [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]), within wound/healing gastrointestinal ulcer relations and angiogenesis is advantageous over standard growth angiogenic factors [7]

doi:10.1007/s12010-011-9436-3 Chen J, Xie L, Cai J, Yang C, Duan X (2013) Enzymatic synthesis of glutathione using engineered Saccharomyces cerevisiae

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Non-approved peptides showed promising preclinical and limited clinical evidence but lack long-term safety data and systematic validation