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Davignon J, Gregg RE, Sing CF

This response impairs the proper folding of proteins, and the resulting accumulation of misfolded proteins can ultimately trigger apoptosis in tumor cells ( The DNA damage caused by heat or ROS production activates the tumor suppressor p53, a key pro-apoptotic factor (Trachootham et al., 2009

Declaration of competing interest The author is an Editorial Board Member/Editor-in-Chief/Associate Editor/Guest Editor for Toxicon: X and was not involved in the editorial review or the decision to publish this article

It also reduces dark eumelanin in favor of the lighter phaeomelanin

Conclusion: Questionnaire-based referral from primary care followed by broadly available fast-track TE and eventually liver biopsy for selected patients is the standard practice in our unit