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MTHFR mutations affect the bodys ability to properly methylate, which can lead to elevated homocysteine levels and impact health

doi: 10.1155/2016/2412958 146 CiminiAD'AngeloBDasSGentileRBenedettiESinghVet al

Cell cycle analysis The position of the cells in the cell cycle was determined by flow cytometric analysis of the DNA content using propidium iodide

Data are presented as MeanSEM

Further studies have shown that genetic knockout of GPX4 induces cell death with characteristic features of ferroptosis, genetically confirming its central role in maintaining cellular lipid homeostasis and defending against oxidative damage (Dixon et al., 2012