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Annu Rev Med 51

This nuance is something we often discuss with researchers exploring compounds for Longevity Research or even Mitochondrial Research, where sustained cellular effects are paramount

Important contraindications include personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), history of pancreatitis, severe gastrointestinal disease including gastroparesis, and pregnancy or planned pregnancy (these medications should be discontinued at least 2 months before a planned pregnancy)

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In comparison to subcutaneous injection, oral administration of EGCG resulted in lower hepatotoxicity, with significant liver damage observed only in mice receiving 108 mg/kg EGCG orally