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300 nM) 103

Acknowledgements We thank Elisabeth Rushing (Institute of Neuropathology, University Hospital Zurich) for support with the analysis of histological sections and Friedhelm Bladt and Frank Jhrling (Merck, Darmstadt, Germany) for providing EMD1214063 and for helpful discussions

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Treatment of cerebral ischemia through NMDA receptors: metabotropic signaling and future directions

Activating these receptors triggers a signaling cascade that upregulates hormone-sensitive lipase, which breaks down stored triglycerides into free fatty acids and glycerol essentially mobilizing stored fat for use as energy