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These hurdles include the inherent complexity and significant inter-individual variability of the axis, challenges in achieving precise and safe interventions, and methodological barriers in clinical trial design and biomarker development, all of which impede rapid bench to bedside translation (163, 164)

Since UV exposure (UVA and UVB) increases melanoma risk, fair-skinned people, with low melanin levels, are more susceptible to UV damage than darker-skinned people

Vitamin C is a well-known antioxidant that helps protect cells from oxidative stress, boosts collagen production, and supports a healthy immune system