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treatment led to complete cessation of tumor growth

However, the effectiveness of PRP therapy can be significantly diminished in individuals with high levels of dihydrotestosterone (DHT)

This metabolite specifically targets and stabilizes PD-L1, which suppresses the activity of tumor-infiltrating T lymphocytes and leads to increased recruitment and activity of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) and tumor-associated macrophages (TAMs) ( In microsatellite stable (MSS) colorectal cancer, tumor cells exhibit asynchronous disruption of the cholesterol biosynthesis pathway, leading to the accumulation of distal cholesterol precursors such as desmosterol and zymosterol

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