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66 In summary, continued discovery of novel AKT substrates involved in GLUT4 translocation indicates that many but not all of the same effectors are involved in the glucose uptake of different tissues, and further studies should be conducted to identify the molecular mediators in all phases of insulin-stimulated glucose uptake

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Nonetheless, as with all biomarkers, real-world sensitivity and specificity remain context-dependent, and blood-based assays like Lumipulse G are best used as complements, not replacements, to comprehensive clinical assessment

pLPCX cyto-roGFP was generated from Cyto-roGFP (Addgene, #49435)