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Methods Ethical considerations All procedures performed in this study were conducted in accordance with the ethical standards of the Brazilian National Research Ethics Committee, as well as the 1964 Declaration of Helsinki and its subsequent amendments, or comparable ethical standards

B., Kolenc, D., Brcic, L., Zarkovic, K., Seiwerth, S., & Sikiric, P

Kindly note that AKT is a kinase protein crucial for the PI3/AKT pathway, and AKT-dn is a negative dominant form of AKT that disturbs its normal function

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Dixon first discovered and named ferroptosis, the critical role of GPX4 in the inhibition of ferroptosis in his study has received widespread attention, mainly in the antioxidant axis system x c - -GSH-GPX4 ( c - is inhibited, obstruction of the cystine transport pathway can decrease GSH and GPX4, which can lead to cell death due to ongoing oxidative stress ( Figure 1A )