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Fatty Acids When anionic lipids (Figure 87) are formulated into LNPs, they can interact with cationic lipids to form ion pairs, which can improve the pH-sensitivity of the LNPs and promote endosomal membrane destabilization, thus increasing nucleic acids delivery efficiency

Metallomics 10 (2), 296308 (2018)

108 Moreover, the SPHK1 inhibitor PF543 also effectively relieved ERS by reducing the phosphorylation of eIF2 and activating ATF6, thus remarkably improving AIH

, 70 , 794-798, Zhang, B., Wang, Y., and Su, Y

Furthermore, in both diseases, this accumulation of lipids has been associated with ER stress and mitochondrial dysfunction, ultimately resulting in cell damage and death (Figure 1) [100]