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Van Kaer L, Postoak JL, Song W, Wu L (2022) Innate and innate-like effector lymphocytes in health and disease

found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

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The lower organic phase was recovered and added with 3 mL of 0.9% NaCl to separate the phase