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Classical features of ferroptosis include impaired antioxidant defenses, reductions in SLC7A11-mediated cystine uptake, diminished GPx4 activity, and the presence of redox-active iron (Bayr et al

Hadden R, Sung V

L-glutathione is a naturally occurring antioxidant produced in the liver, composed of the amino acids L-glutamic acid, L-cysteine, and L-glycine

Subsequent developments in ionization techniques like electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI), along with enhancements in chromatographic separation technologies such as ultra-high performance liquid chromatography (UPLC) and high-performance liquid chromatography (HPLC), propelled chromatography-mass spectrometry coupling towards higher throughput and greater versatility