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Bruceine d elevates Nrf2 activation to restrain Parkinson's disease in mice through suppressing oxidative stress and inflammatory response

Blocking targeted xCT can effectively reduce cysteine uptake, leading to glutathione depletion and enhancing the sensitivity of tumor cells to chemotherapy

Through coordinated implementation of these strategies and interdisciplinary collaboration, the translation of medicine-food homologous TCM bioactives into regulated and industrialized functional foods or dietary supplements for PD can be acceleratedoffering patients safer, more effective, and longer-lasting adjunctive therapeutic options

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Several studies have revealed that curcumin modulates epigenetics in neurological diseases and neuroinflammation (162, 163)