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Since apigenin and ellagic acid modulate complementary pathways including AMPK activation, NF-B inhibition, and CYP17A1 or 5-reductase suppression, their combined use may provide broader benefits than either compound alone

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A., Engels, F., van der Vliet, H

Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis

This did not fluctuate significantly with addition of platelets & albumin, or IBD duration & PSC duration in the model