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The third major target is the selenoenzyme GPx4

Therapeutic strategies for Glaucoma and optic neuropathies

When these levels are off, you can experience symptoms like muscle cramps, fatigue, and headaches

Research has found that, conversely, in a streptozotocin-induced type 1 diabetes rat model, reducing FPN levels leads to increased brain iron, causing ferroptosis, and ultimately resulting in cognitive impairment and decline (Hao et al., 2021)