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All of the studied enzymes work in an integrated way, which allows the cell to adapt to stressful conditions associated with impaired redox balance

Antidepressant effect of anti-inflammatory treatments in older adults For studies with older patients with a diagnosis of depression, most of them (9 trials) used a placebo as the control group, except for two studies [46, 53, 54]

PMID: 25225435

Lack of adaptive detoxification enzyme induction is known to occur in response to accumulating toxins [63]

Consistent with a moderate increase of these well-described changes in healthy aging, we observed significantly higher levels of malondialdehyde (MDA), a marker for circulating levels of lipid peroxides, in older adults compared to the levels of young subjects (means, young = 0.136, older adults = 0.158 mol/L, p -value 300 uM in older adults is within the range of what has been described as being associated with elevated cardiovascular risk compared to that of young subjects (El-Khairy et al., 2001)