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However, multidrug insensitivity or acquired resistance to existing traditional chemotherapy remains a major challenge for oncology treatment

doi: 10.1016/j.biopha.2024.116722 38 LongoU

EC 2.7.1.105), which catalyzes the formation of fructose 2,6-bisphosphate (F2,6BP) from fructose 6-phosphate

Supporting these observations, TAMs from Lewis lung cancer (M2 phenotype) was reported to express higher levels of the glutamine metabolizing enzymes, transaminase and glutamine synthetase