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You can imagine the issues that might arise if these important processes were not fully functioning

Some natural compounds also influence the metabolic pathways of microorganisms, increasing the abundance of active secondary metabolites

Pharmacol Res (2016) 103:14957

Kruidenier L, Kuiper I, Lamers CBHW, Verspaget HW

To the best of our knowledge the first study to suggest an association between iron metabolism and AML cell chemosensitivity described an association between decreased AML-free survival and an AML cell phenotype characterized by the altered mRNA expression of several regulators of the cellular iron metabolism (including decreased levels of several vacuolar ATPase components)