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In hypothyroidism, reduced thyroid hormone signaling first produces a redox imbalance marked by decreased synthesis of selenoproteins such as glutathione peroxidases and thioredoxin reductases ( In hyperthyroidism, accelerated mitochondrial metabolism produces excessive reactive oxygen species (ROS), overwhelming endogenous antioxidant defenses ( Hypothyroidism reduces the expression of tight junction proteins, increasing permeability and facilitating immune cell infiltration ( 4 Plant-based nutritional strategies for thyroidbrain axis support Given that oxidative stress, neuroinflammation, and neurotransmitter disturbances are central drivers of thyroidbrain axis dysfunction, dietary and plant-derived nutritional components that can modulate these interconnected pathways have a clear theoretical rationale

Table 2 Effect of transcriptomic factors on male infertility

Small sample sizes, brief intervention durations, and varied supplementation protocols with regard to dosage, formulation, and combinations are common limitations of clinical trials

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