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Tumor cells express high levels of the methionine transporter large neutral amino acid transporter small subunit (encoded by SLC43A2 ), which competes for methionine with CD8+ TILs and disrupts methionine metabolism in CD8+ TILs (Fig

Cell viability assay For the cell viability assays, cells were plated in a 96-well plate at a density of 2 10 4 /well and treated with carboplatin

For these quantified metabolites, we used conditional logistic regression models implemented via the survival R package, accounting for the matched study design (matched on age, sex, and race)