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Emerging evidence suggests a bidirectional relationship between gut health and brain function, often referred to as the gut-brain axis. Intestinal I/R injury, as a form of acute gut stress, has been implicated in triggering systemic inflammatory responses that extend beyond the gut, to impact distant organs, including the brain (Osadchiy et al., 2019)

However, the "top-down" approach only works if you use a high-bioavailability format

Folinic acid is also sometimes used to prevent the toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine

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Functional symptoms in neurology: management