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Santos Department of Epidemiology and Health Promotion, New York University, New York, NY, USA Habib Benzian School of Health Science, Bahir Dar University, Bahir Dar, Ethiopia Alemshet Yirga Berhie Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA Adam E

It also reduces inflammation

doi: 10.3389/fimmu.2021.635899 Received 30 November 2020 Accepted 18 February 2021 Published 11 March 2021 Volume 12 - 2021 Edited by Paola Zacchi, University of Trieste, Italy Reviewed by Tiziana Schioppa, University of Brescia, Italy

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Gut microbiota-derived 3-hydroxybutyrate blocks GPR43-mediated IL6 signaling to ameliorate radiation proctopathy