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ROS directly damage IECs, activate mucosal immune responses, and trigger oxidative stress-related signaling pathways such as NF-B and nuclear factor erythroid 2-related factor 2 (Nrf2), thereby aggravating barrier dysfunction and chronic inflammation (100, 101)

Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes

doi:10.1098/rstb.2013.0213

To boost glutathione levels in the body, precursors such as whey protein, vitamin C, and glutamine are often recommended

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