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The K1 Cagri rotamer resides in a similar position to the non-acylated K1 rAmy 15 , and this contrasts with the orientation observed in the Cagri-AMY 1 R-Gs complex

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S.et al.2010Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors, 32