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Abnormal expression of miRNA can be triggered by long-term environmental stressors, such as oxidative stress, toxins, or pathogens that induce both physiological and pathological stress

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Downstream of HIFiron remodeling, ferroptosis in intestinal epithelial cells (IECs) constitutes a key mechanism that converts upstream threshold shifts into epithelial barrier failure and inflammatory amplification in IBD

Doctors may also inject a small amount of local anesthetic into the joint, which can be used as a diagnostic tool