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Another example was observed in hematopoietic stem cells, where the R172H mutp53 promoted greater ability to self-renew in vitro and in vivo compared to wtp53 loss, showing that FOXH1, a regulator of stem cell factor receptor c-Kit and SCA-1 (Stem Cell Antigen 1), was necessary for this phenotype in cells expressing mutp53 (Loizou et al., 2019)

[123] Although there have been many studies on the role of vitamin D in the development of autism, the majority of them are limited by their inability to assess the deficiency prior to an autism diagnosis

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Figure 3 Structural insights into ghrelin recognition by the ghrelin receptor Following the publication of the inactive ghrelin receptor structure in 2020, a series of ghrelin receptor structures were determined using cryo-EM and subsequently reported (Wang et al., 2021

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