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Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms

In fact, data has shown that higher levels of IGF-1 in older adults helps to prevent neuronal loss and age-related cognitive decline, specifically in terms of protecting against Parkinsons and Alzheimers

BPC 157 10mg $85.90 BPC-157 is a partial sequence of body protection compound (BPC) found in human gastric juice

10.1074/mcp.M111.014142 Mol

There are still some concerns about this change, particularly that it wont come into effect until June 2027