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Pretreatment with L-citrulline has been shown to significantly elevate intracellular NO concentrations ( Figure 3a ), thereby effectively attenuating pathological mitochondrial fission

10.1016/j.fm.2011.07.011 Forde BM, Neville BA, ODonnell MM, Riboulet-Bisson E, Claesson MJ, Coghlan A, Ross RP, OToole PW: Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts

A similar pattern was observed in the phylogenetic tree constructed based on amino acid sequences derived from fungal gdh2 nucleotides

In a randomized clinical trial, the antioxidant astaxanthin, in combination with collagen peptides, improved facial skin elasticity and hydration and reduced matrix metalloproteinase expression while increasing endogenous collagen expression 54 , suggesting enhanced collagen homeostasis

Figure 1 summarizes these simple concepts, illustrating the binding of NTs to the receptor and the activation of signaling of different functions