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doi: 10.1016/j.sleep.2018.05.034 75

In the literature, a statistically significant decrease in OPG activity was observed in rats with periodontitis compared with control groups [38, 56, 57]

In parallel, glutamate metabolism is disrupted, and excess glutamate contributes to motor neuron degeneration through excitotoxicity, calcium overload, and modulation of astrocytic reactivity 14