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A better understanding of the detailed interactions between the factors involved will contribute to further elucidate the cell defense capability, which is impaired in neurodegenerative diseases such as ALS [67, 141, 170], and may reveal the path for identifying novel potential therapeutic targets

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In addition, Proteobacteria are rich in lipopolysaccharides and flagellin, which are recognized by TLRs of AMs to cause oxidative stress damage to cells and release inflammatory mediators such as IL-1, IL-6, TNF-, and nuclear factor (NF)-B, thereby recruiting more neutrophils and macrophages

High levels of homocysteine increase the risk of cardiovascular disease

Cell isolation and scRNA-seq experiments For all scRNA-seq experiments, Esm1-CreERT2 tg/+ and R26-mTmG tg/+ E18.0 embryos (injected with 2 mg 4-OHT at E17.0) were dissected in ice-cold PBS