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Higher doses of TM elicited UPR activation in ET-treated cells to an extent comparable to that observed with lower doses in non-ET-treated cells (Figure 2C)

Our data suggest that hypermethylation of the 25-hydroxylases, 1--hydroxylase enzymes, and the vitamin D receptor promoter, accompanied by hypomethylation of CYP24A1, leads to impaired expression and possibly a predisposition to VD deficiency/inadequacy

Pharmacological inhibition of HDAC by VPA restored histone H3 acetylation levels, reversed synaptic plasticity aberrations and improved the epileptic phenotype in TSC2 +/ mice

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He checked my vitamin levels and they were very low