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The report recognizes the polygenic and multifactorial nature of antidepressant response, proposing that other pharmacodynamic genes (e.g., SLC6A4, HTR2A, ADRA2A) may interact with CYP-mediated pharmacokinetics to shape overall efficacy (van Westrhenen et al., 2020)

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This abrupt awakening can occur even after severe poisoning and can make airway management more difficult

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46 Cytochrome P450-dependant metabolism acts as a reactive oxygen species generator and participates in cell apoptosis

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