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Importantly, palifermin is generally not utilized as a standalone therapeutic agent but rather in conjunction with other immune-enhancing therapies

however, it encounters significant bioavailability challenges that may limit therapeutic effectiveness [74, 76]

Consistently, CD147 was co-localized and interacted with MCT1 or LDHB in the mitochondria of lung metastases from lactate-administered TNBC PDX1/2 (Figs