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As a separate response to oxidative stress, studies have suggested that EGFR-mediated NADPH oxidase (NOX) assembly facilitates ROS generation in GBM [82, 83]

Peptide-targeted cytotoxic peptides Cationic amphipathic peptides with inherent cytotoxicity exhibit advantages: they can attenuate multidrug resistance in tumor cells and present broad-spectrum antitumor activities 47,48