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Our results on the liver injury of single time APAP overdose along with alcohol ingestion at different time scenarios relative to the overdose matched with the observation of clinical studies that shows that simultaneous ingestion of alcohol and APAP and intake of alcohol after APAP overdose for non-alcoholic individuals results in lesser production of NAPQI with decreased risk of hepatotoxicity (see Chien, Thummel, and Slattery 1997)