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Specific amino acids within the IGF-1 molecule have been shown by site-directed mutagenesis to account for receptor and/or binding protein association (Table 24-1)

It binds to specific receptors on the pituitary gland, prompting the gland to produce and release HGH

Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-Guggulsterone and Gugulipid extract of ayurvedic medicine plant Commiphora mukul

Conclusion Ipamorelin and CJC-1295 represent two of the most pharmacologically well-characterised GH secretagogue peptides available for research use, with complementary receptor mechanisms that make them particularly valuable as paired tools for investigating the hypothalamic-pituitary GH axis

The use of different moieties has been extensively discussed in other works and goes beyond the scope of the present paper (Blanco et al., 2015)